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https://doi.org/10.5281/zenodo.3903937

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Conflictos de Interés: La autora declara que no tiene conflictos de interés.

Fuentes de Financiamiento: Ninguna.

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Sugerencia de cita: Jiménez-Arellanes MA. Silimarina como potencial agente hepatoprotector. Rev Cadena Cereb. 2019; 3(2): 60-70.

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Recibido: 17/01/2020.

Aceptado: 02/05/2020.

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RESUMEN

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El hígado es el encargado de la homeostasis y de metabolizar diversas sustancias (endógenas y exógenas, incluyendo fármacos), las cuales al metabolizarse generan metabolitos más tóxicos y/o reactivos; por esto el hígado es más susceptible de sufrir algún daño como cirrosis, esteatosis y/o hasta hepatocarcinoma. El ser humano ha empleado diversas plantas medicinales (PM) desde tiempos ancestrales para tratar sus padecimientos, enfermedades y dolencias; entre ellas esta Sylibum marianum. Planta utilizada en el tratamiento de ictericia u otras enfermedades biliares; así como, en terapia de apoyo en la intoxicación por hongos y en el tratamiento de diversas enfermedades hepáticas. A partir de esta especie medicinal se obtiene la silimarina (mezcla de flavonoides), esta sustancia tiene importante efecto antioxidante, también tiene diversas actividades biológicas como hepatoprotector. Esta actividad se ha demostrado mediante diversos estudios preclínicos y clínicos.

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Palabras Clave: Silimarina, hepatotoxicidad, silibina, hepatoprotector, nefroprotector.

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ABSTRACT

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The liver is in charge of homeostasis and of metabolizing various substances (endogenous and exogenous, including drugs), many of which, when metabolized, generate more toxic and/or reactive metabolites, for this reason, the liver is more susceptible to suffer some damage such as cirrhosis, steatosis and/or even hepatocarcinoma. The humanity has been used several medicinal plants (PM) since ancestral times to treat their ailments, diseases and ailments; among them is Sylibum marianum, that has been used in the treatment of jaundice or other biliary diseases; as well as, in supportive therapy in fungal poisoning and in the treatment of some liver diseases. From this medicinal plant has been obtained sylimarin (flavonoids mixture), this substance has significative antioxidant effect, also has some biological activities such as hepatoprotective. This activity has been demonstrated by preclinical and clinical trials.

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Key words: Silymarin, hepatotoxicity, silibin, hepatoprotective, nephroprotective.

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